Fludioxonil

Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].

Product Specifications

CAS Number

[131341-86-1]

Product Name Alternative

CGA-173506

UNSPSC

12352200

Hazard Statement

H410

Target

Apoptosis; Fungal

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/fludioxonil.html

Purity

99.97

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

N#CC1=CNC=C1C2=C3OC(F)(F)OC3=CC=C2

Molecular Formula

C12H6F2N2O2

Molecular Weight

248.19

Precautions

H410

References & Citations

[1]Yabing Duan, et al. effect of phenylpyrrole fungicide fludioxonil on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pesticide Biochemistry and Physiology Volume 106, Issues 1-2, May-June 2013, Pages 61-67.|[2]Ryeo-Eun Go, et al. Fludioxonil induced the cancer growth and metastasis via altering epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in cellular and xenografted breast cancer models. Environ Toxicol. 2017 Apr;32 (4) :1439-1454. |[3]Imen Graiet, et al. Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells. Food Chem Toxicol. 2022 Dec:170:113464.|[4]Su-Min Seong, et al. Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models. Environ Toxicol. 2024 May;39 (5) :2993-3002.