Uridine 5′-diphosphoglucose-13C (disodium)

Uridine 5′-diphosphoglucose-13C (UDP-D-Glucose-13C) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) [1]. Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR) -induced inflammation in the heart tissue[2][3][4][5].

Product Specifications

CAS Number

[478529-38-3]

Product Name Alternative

UDP-D-Glucose-13C (disodium)

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; P2Y Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/uridine-5-diphosphoglucose-13c-disodium.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](O)[C@@H](COP(OP(O[13C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)(O[Na])=O)(O[Na])=O)O[C@H]1N3C=CC(NC3=O)=O

Molecular Formula

C14 13CH22N2Na2O17P2

Molecular Weight

611.26

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition) . 1974;4:2225-2228.; Das A, et al. Human P2Y (14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacemen|[3]Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805. |[4]Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30 (1) :27-34.|[5]Das A, et al. Human P2Y (14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53 (1) :471-80.