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Tubulin inhibitor 41

Selected Variant

HY-161256

Size: 1 Each

Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells[1].

Product Specifications

CAS Number

2770273-12-4

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-inhibitor-41.html

Solubility

10 mM in DMSO

Smiles

N#CC(C1C2=CC=CC=C2)=C(N)OC3=C1C=CC4=C3N=C(C)C=C4

Molecular Formula

C20H15N3O

Molecular Weight

313.35

References & Citations

[1]Haoyi Yang, et al. Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent. Eur J Med Chem. 2024 Feb 8:267:116205.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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