Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PTEN (Phospho-Ser380/Thr382/Thr83) Antibody

Rabbit Polyclonal Antibody specific to PTEN (Phospho-Ser380/Thr382/Thr83)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-PTEN (Phospho-Ser380/Thr382/Thr83) Rabbit Polyclonal Antibody

UniProt

P60484

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence that includes phosphorylation site of Serine 380/threonine 382/threonine 383 derived from human PTEN and conjugated to KLH.

Target

PTEN (Phospho-Ser380/Thr382/Thr83)

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC, IF

Field of Research

Phosphospecific Antibodies

Purification Method

Affinity-purified on phosphopeptide; non-phosphopeptidereactive antibodies were removed by chromatography on non-phosphorylated peptide

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Immunoblotting: use at dilution of 1:500-1:1,000. A band of ~54kDa is detected. <br><br>Immunohistochemistry: use at dilution of 1:50-1:100. <br><br>Immunofluorescence: use at dilution of 1:100-1:200. <br><br>These are recommended working dilutions. <br><br>End user should determine optimal dilutions for their application.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody detects endogenous human, mouse, and rat PTEN only when phosphorylated at serine 380 and threonine 382/383.Accession no.: P60484, NP_000305.3

Formulation

PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Buffer pH

pH 7.4

Target Background

Phosphatase and tensin homolog (PTEN) was identified as a tumor suppressor that is mutated in many cancers. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to the dual specificity protein tyrosine phosphatases. Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol- 3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PE Anti-Rat CD44H Antibody[OX-49]
E-AB-F1225UD-01 25 µg

PE Anti-Rat CD44H Antibody[OX-49]

Sign In for Pricing
View Details
PE Anti-Rat CD44H Antibody[OX-49]
E-AB-F1225UD-02 100 µg

PE Anti-Rat CD44H Antibody[OX-49]

Sign In for Pricing
View Details
PE Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5]
E-AB-F1120UD-01 25 µg

PE Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5]

Sign In for Pricing
View Details
PE Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5]
E-AB-F1120UD-02 100 µg

PE Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5]

Sign In for Pricing
View Details
(4E, 8Z)-Sphingadienine-C18-1-phosphate
TRC-S680655-1MG 1 mg

(4E, 8Z)-Sphingadienine-C18-1-phosphate

Sign In for Pricing
View Details
ATRX / RAD54 (Alpha Thalassemia Mental Retardation) (23c), CF568 conjugate, 0.1mg/mL
BNC681474-100 1x 100 µL

ATRX / RAD54 (Alpha Thalassemia Mental Retardation) (23c), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details