SLC7A11-IN-2
SLC7A11-IN-2 (Compound 1) is an SLC7A11/xCT inhibitor. SLC7A11-IN-2 induces cell death in HeLa cells by lowering intracellular glutathione levels and increasing oxidative stress, thereby disrupting the oxidative balance within the cells, with an IC50 value of 10.23 μM. Molecular dynamics simulation analysis indicates that SLC7A11-IN-2 has a stronger binding affinity to SLC7A11 compared to Erastin (HY-15763) . SLC7A11-IN-2 can be utilized in research within the field of cervical cancer[1].
Product Specifications
CAS Number
[14668-59-8]
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/slc7a11-in-2.html
Purity
99.80
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(C(CC(CC)O)C(NNC1=CC=CC=C1)=O)NNC2=CC=CC=C2
Molecular Formula
C19H24N4O3
Molecular Weight
356.42
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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