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Ciprofloxacin

Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].

Product Specifications

CAS Number

[85721-33-1]

Product Name Alternative

Bay-09867

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial; Mitochondrial Metabolism; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Ciprofloxacin.html

Purity

99.96

Solubility

0.1 M HCl : 16.67 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C) |DMSO : 4.86 mg/mL (ultrasonic; warming; adjust pH to 5 with 1 M HCl; heat to 60°C) |H2O : 6.78 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)

Smiles

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O

Molecular Formula

C17H18FN3O3

Molecular Weight

331.34

Precautions

H315, H319, H335

References & Citations

[1]Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58 (6) :1657-63.|[2]Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61 (5) :e02434-16.|[3]Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91.|[4]LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153 (9) :e181804.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Quinolone

Citation 01

Adv Sci (Weinh) . 2020 Jul 21;7 (17) :2001374.|Anal Chim Acta. 2022 Aug 15:1221:340082.|Anim Dis. 2021;1 (1) :26.|Antimicrob Agents Chemother. 2025 May 23:e0024925.|Appl Biochem Biotechnol. 2025 Aug 23.|Appl Microbiol Biotechnol. 2022 Apr;106 (7) :2689-2702.|Arab J Chem. 2024 May, 17, 5, 105745.|bioRxiv. 2024 May 10.|bioRxiv. 2024 Nov 06.|Cardiovasc Toxicol. 2024 Sep;24 (9) :889-903.|Chemosphere. 2019 Jun:225:378-387.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|EBioMedicine. 2022 Apr;78:103943.|Eur J Clin Microbiol Infect Dis. 2025 Sep 29.|Front Microbiol. 2022 Feb 16:12:773664.|Genome Biol. 2023 Apr 30;24 (1) :98.|Infect Drug Resist. 2025 Oct 4:18:5239-5247.|Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.|iScience. 2023 Oct 7;26 (11) :108158.|J Antimicrob Chemother. 2020 Jul 1;75 (7) :1850-1858.|J Med Chem. 2025 Dec 11;68 (23) :25274-25289.|Microb Pathog. 2024 Jun:191:106666.|Microbiol Spectr. 2022 Apr 25:e0251821.|Microbiol Spectr. 2022 Feb 23;10 (1) :e0099121.|Microbiol Spectr. 2025 May 19:e0307424.|Molecules. 2023 Jun 8;28 (12) :4628.|Nat Cell Biol. 2024 Sep;26 (9) :1545-1557.|Nature. 2024 Aug;632 (8027) :1137-1144.|NPJ Biofilms Microbiomes. 2024 Oct 28;10 (1) :111.|Orebro University. 2024.|Patent. US20200101105A1.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Research Square Preprint. 2020 Jun.|Vet Microbiol. 2024 May:292:110046.|Virulence. 2024 Dec;15 (1) :2415952.|Water Res. 2023 Jul 15:240:120110.|Water Res. 2024 Nov 29:271:122885.|Water. 2025 Jun 6.|ACS Appl Polym Mater. 2023 Aug 29.|bioRxiv. 2024 Jan 18.|Chem Eng J. 2025 May 1.|Anim Dis. 2021;1 (1) :26.|Arch Pharm Res. 2025 Jan;48 (1) :102-114.|bioRxiv. 2024 Feb 9.|Nat Commun. 2022 Mar 2;13 (1) :1116.

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