BMS-986172
BMS-986172 is an orally active and selective Monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC50 of 4.6 nM and 20 nM for hMGAT2 and mMGAT2, respectively. BMS-986172 reduces food intake and body weight. BMS-986172 can be used for the researches of metabolic diseases, such as obesity [1].
Product Specifications
CAS Number
1808258-99-2
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bms-986172.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C([C@]2(C(F)(F)F)CC(C3=NN(C=C3)CC4CC4)=C(C(N2)=O)N5N=NNC5=O)C=CC(OCCCC(F)(F)F)=C1
Molecular Formula
C24H22F7N7O3
Molecular Weight
589.47
References & Citations
[1]Wei Meng, et al. Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders. J Med Chem. 2023 Sep 28;66 (18) :13135-13147.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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