Osivelotor
Product Specifications
UNSPSC Description
Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/osivelotor.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N=CC=C1)CCO)N2[C@@H](COCC2)COC3=C(C(O)=CC=C3)C=O
Molecular Weight
386.40
References & Citations
[1]WHO Drug Information-World Health Organization (WHO).|[2]Dufu K, et al. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202(1):173-183.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148788/Osivelotor-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148788/Osivelotor-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2417955-18-9
Available Sizes
Curated Selection
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