Amustaline (dihydrochloride)

Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) [1][2].

Product Specifications

CAS Number

[210584-54-6]

Product Name Alternative

S-303 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H360

Target

Bacterial; CHIKV; HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/amustaline-dihydrochloride.html

Concentration

10mM

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl.[H]Cl.[H]Cl

Molecular Formula

C22H27Cl4N3O2

Molecular Weight

507.28

Precautions

H301, H315, H319, H360

References & Citations

[1]Aubry M, et, al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components. Vox Sang. 2018 Apr;113 (3) :232-241.|[2]Mufti NA, et, al. Treatment of whole blood (WB) and red blood cells (RBC) with S-303 inactivates pathogens and retains in vitro quality of stored RBC. Biologicals. 2010 Jan;38 (1) :14-9.|[3]North A, et, al. Preclinical pharmacokinetic and toxicology assessment of red blood cells prepared with S-303 pathogen inactivation treatment. Transfusion. 2011 Oct;51 (10) :2208-18.