Defactinib analogue-1
Defactinib analogue-1 (Compound 7) is a ligand for target protein Fak, that can be used for synthesis of PROTAC FAK degrader 1 (HY-119932) [1].
Product Specifications
CAS Number
[2296719-34-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FAK; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/defactinib-analogue-1.html
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CS(=O)(N(C)C1=CC=CC(CNC2=NC(NC3=CC=C(O)C=C3)=NC=C2C(F)(F)F)=C1)=O
Molecular Formula
C20H20F3N5O3S
Molecular Weight
467.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140 (49) :17019-17026.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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