Acefylline (Standard)

Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505) . This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research[1][2][3].

Product Specifications

CAS Number

[652-37-9]

Product Name Alternative

Theophyllineacetic acid (Standard) ; Theophylline-7-acetic acid (Standard)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adenosine Receptor; Phosphodiesterase (PDE) ; Protein Arginine Deiminase; Reference Standards

Type

Reference Standards

Related Pathways

Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/acefylline-standard.html

Smiles

O=C(O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O

Molecular Formula

C9H10N4O4

Molecular Weight

238.20

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14 (1) :31-6.|[2]Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81 (2) :101-6.|[3]Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56 (2) :251-7. PMID: 16613730.