(S) -Terazosin

(S) -Terazosin is an active S-enantiomer of Terazosin. (S) -Terazosin is a potent and high-affinity α-adrenoceptor antagonist with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S) -Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively[1].

Product Specifications

CAS Number

[109351-33-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/s-terazosin.html

Purity

99.71

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@H]4OCCC4

Molecular Formula

C19H25N5O4

Molecular Weight

387.43

Precautions

H315, H319, H320

References & Citations

[1]Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15 (7-8) :863-85.