SM1044
SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC50 [1].
Product Specifications
CAS Number
[1331880-08-0]
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sm1044.html
Smiles
C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
Molecular Formula
C34H55NO10
Molecular Weight
637.80
References & Citations
[1]Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9 (1) :15528.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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