Remdesivir-d5

Remdesivir-d5 (GS-5734-d5) is a deuterium labeled Remdesivir (HY-104077) . Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection[1][2][3].

Product Specifications

Product Name Alternative

GS-5734-d5

UNSPSC

12352005

Target

DNA/RNA Synthesis; Isotope-Labeled Compounds; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.86

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)

Smiles

C[C@H](N[P@@](OC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O

Molecular Formula

C27H30D5N6O8P

Molecular Weight

607.61

References & Citations

[1]Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30 (3) :269-271.|[2]Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9 (2) . pii: e00221-18.|[3]Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65 (18) :12044-12054.