Coenzyme Q0

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].

Product Specifications

CAS Number

[605-94-7]

Product Name Alternative

CoQ0

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Akt; Apoptosis; Autophagy; Bcl-2 Family; Caspase; COX; EGFR; Interleukin Related; MMP; mTOR; NF-κB; NO Synthase; PARP; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/coenzyme-q0.html

Purity

99.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(OC)=C(OC)C(C(C)=C1)=O

Molecular Formula

C9H10O4

Molecular Weight

182.18

Precautions

H315, H319, H335

References & Citations

[1]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[2]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[3]Yang HL, et, al. Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells. Biochem Pharmacol. 2015 Nov 1;98 (1) :144-56.