Mannan

Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR) . Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615) -induced toxicity, and reduces lipid[1][2][3][4].

Product Specifications

CAS Number

[9036-88-8]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; Glycosidase; Interleukin Related; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mannan.html

Purity

98.00

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Mannan]

Precautions

H302, H315, H319, H335

References & Citations

[1]Mathiesen R, et al. Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells. Front Immunol. 2019 Nov 15;10:2646.|[2]Madrigal-Santillán E, et al. Inhibitory effect of mannan on the toxicity produced in mice fed aflatoxin B1 contaminated corn. Arch Environ Contam Toxicol. 2007 Oct;53 (3) :466-72.|[3]Funayama H, et al. Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. Int Immunopharmacol. 2009 Dec;9 (13-14) :1518-24.|[4]Goncharova NV, et al. Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407. Bull Exp Biol Med. 2016 Nov;162 (1) :18-22.