PROTAC SMARCA2/4-degrader-34
PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein ; Black: Linker (HY-43048) ; Blue: Ligand for E3 ligase (HY-125845).
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Pregnane X Receptor (PXR) ; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-34.html
Smiles
O=C(C1=CC=C(C(NC(C2=C(N(N=N2)C3=CC(OC)=C(C=C3OC)OCCCCCCOCCOCC(N[C@H](C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)C(C)(C)C)=O)C)=O)=C1)O[C@@H](CC)CCC)OC
Molecular Formula
C58H78N8O13S
Molecular Weight
1127.35
References & Citations
[1]Huber AD, et al. First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy. J Med Chem. 2024 Oct 24;67 (20) :18549-18575.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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