NNC 63-0532

NNC63-0532 is a novel non-peptide nociceptin receptor (ORL1) agonist, with EC50s of 305 nM. NNC63-0532 plays important roles in many disorders such as pain, drug addiction[1].

Product Specifications

CAS Number

[250685-44-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nnc-63-0532.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(OC)CN1CN(C2=CC=CC=C2)C3(CCN(CC4=C5C=CC=CC5=CC=C4)CC3)C1=O

Molecular Formula

C27H29N3O3

Molecular Weight

443.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]C Thomsen, et al. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl) -acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br J Pharmacol. 2000 Nov;131 (5) :903-8.