Alamethicin

Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes[1][2].

Product Specifications

CAS Number

[27061-78-5]

UNSPSC

12352209

Hazard Statement

H301

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/alamethicin.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C(C(NC([C@@H](NC(CNC(C(NC([C@@H](NC(C(NC([C@@H](NC([C@@H](NC(C(NC([C@@H](NC(C(NC(=O)[C@H]1N(C(C(NC(C)=O)(C)C)=O)CCC1)(C)C)=O)C)=O)(C)C)=O)C)=O)CCC(N)=O)=O)(C)C)=O)[C@H](C)C)=O)(C)C)=O)=O)CC(C)C)=O)(C)C)(=O)N2[C@H](C(N[C@H](C(NC(C(NC(C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)(C)C)=O)(C)C)=O)[C@@H](C)C)=O)CCC2

Molecular Formula

C92H150N22O25

Molecular Weight

1964.34

Precautions

H301

References & Citations

[1]Olga S.Ostroumova, et al. Chapter Six-Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.|[2]Barns KJ, et al. Single-cell, time-resolved study of the effects of the antimicrobial peptide alamethicin on Bacillus subtilis. Biochim Biophys Acta. 2016 Apr;1858 (4) :725-32.