DPTIP

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].

Product Specifications

CAS Number

[351353-48-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dptip.html

Concentration

10mM

Purity

99.55

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

COC1=CC(C2=NC(C3=CC=CC=C3)=C(N2)C4=CC=CS4)=CC(OC)=C1O

Molecular Formula

C21H18N2O3S

Molecular Weight

378.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8 (1) :17715.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.