Val-Cit-Exatecan (TFA)
Val-Cit-Exatecan TFA is an agent-linker conjugate for ADC. Val-Cit-Exatecan TFA is composed of a DNA topoisomerase I Exatecan and a cathepsin cleavable ADC linker[1].
Product Specifications
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/val-cit-exatecan-tfa.html
Smiles
CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NCOCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C40H48F4N8O11
Molecular Weight
892.85
References & Citations
[1]Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17 (6) :e254-e262
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
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