PDGFR Y1021 peptide (non-phosphorylation)

PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR) . PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response[1].

Product Specifications

CAS Number

[205173-94-0]

UNSPSC

12352209

Target

Mitosis; PDGFR

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pdgfr-y1021-peptide-non-phosphorylation.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

Molecular Formula

C64H98N14O21

Molecular Weight

1399.54

References & Citations

[1]Valius M, et al., Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol. 1993 Jan;13 (1) :133-43.