Bithionol

Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM) [1][2].

Product Specifications

CAS Number

[97-18-7]

UNSPSC

12352005

Hazard Statement

H300

Target

Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Bithionol.html

Purity

99.32

Solubility

DMSO : ≥ 33 mg/mL

Smiles

OC1=C(Cl)C=C(Cl)C=C1SC2=CC(Cl)=CC(Cl)=C2O

Molecular Formula

C12H6Cl4O2S

Molecular Weight

356.05

Precautions

H300

References & Citations

[1]Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD) . Dis Aquat Organ. 2010 Sep 17;91 (3) :257-62.|[2]Silke Kleinboelting, et al. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291 (18) :9776-84. |[3]J Maki, et al. Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature Hymenolepis nana in mice. J Helminthol. 1985 Sep;59 (3) :211-6.