Myriocin

Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection[1][2][3].

Product Specifications

CAS Number

[35891-70-4]

Product Name Alternative

Thermozymocidin; ISP-I

UNSPSC

12352211

Hazard Statement

H301

Target

Antibiotic; HCV

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/myriocin.html

Purity

99.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCC(CCCCCC/C=C/C[C@@H](O)[C@H](O)[C@](CO)(N)C(O)=O)=O

Molecular Formula

C21H39NO6

Molecular Weight

401.54

Precautions

H301

References & Citations

[1]He Q, et, al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. Mycopathologia. 2004 Apr;157 (3) :339-47.|[2]Amemiya F, et, al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197 (3) :361-70.|[3]Ciesek S, et, al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198 (7) :1091-3.