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Apamin (TFA)

Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1].

Product Specifications

Product Name Alternative

Apamine (TFA)

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/apamin-tfa.html

Purity

97.03

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1[C@@]2([H])N(C([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@H](CSSC[C@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N)=O)CC4=CN=CN4)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](N1)CCC(O)=O)=O)([H])[C@H](O)C)=O)C)=O)CC(C)C)=O)N)=O)CC(N)=O)=O)=O)CCCCN)=O)C)=O)CCC2.O=C(O)C(F)(F)F

Molecular Formula

C81H132F3N31O26S4

Molecular Weight

2141.36

References & Citations

[1]Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39 (5) :1188-1194.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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