1-Methylisatin

1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo[1][2].

Product Specifications

CAS Number

[2058-74-4]

Product Name Alternative

N-Methylisatin

UNSPSC

12352005

Hazard Statement

H301, H315, H318, H335

Target

Carboxylesterase (CES)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-methylisatin.html

Purity

99.81

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1N(C)C2=C(C=CC=C2)C1=O

Molecular Formula

C9H7NO2

Molecular Weight

161.16

Precautions

H301, H315, H318, H335

References & Citations

[1]Hyatt JL, et al. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50 (8) :1876-85.|[2]Mandal P, et al. Fluorescence spectroscopic characterization of the interaction of human adult hemoglobin and two isatins, 1-methylisatin and 1-phenylisatin: a comparative study. J Phys Chem B. 2009 Nov 12;113 (45) :14904-13.