Ribociclib (Standard)

Ribociclib (Standard) is the analytical standard of Ribociclib. This product is intended for research and analytical applications. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

Product Specifications

CAS Number

[1211441-98-3]

Product Name Alternative

LEE011 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ribociclib-standard.html

Purity

99.76

Smiles

O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5

Molecular Formula

C23H30N8O

Molecular Weight

434.54

Precautions

H302, H315, H319, H335

References & Citations

[1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21 (13) :2905-10.|[2]Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19 (22) :6173-82.