Propargyl-PEG5-NHS ester
Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1393330-40-9]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg4-c2-nhs-ester.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
Molecular Formula
C18H27NO9
Molecular Weight
401.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhenjun Diwu, et al. Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection. US20170275418A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
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