1D228
1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors[1].
Product Specifications
CAS Number
2925447-16-9
UNSPSC
12352005
Target
C-Met/HGFR; Trk Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
[2H][C@@](C1=CC=CC(C2=NC=C(C=N2)OCC3CCN(CC3)C)=C1)(N4N=C(C=CC4=O)C5=CC=CC(C#N)=C5)C
Molecular Formula
C30H29DN6O2
Molecular Weight
507.60
References & Citations
[1]An B, et al. A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation. Cell Death Dis. 2023 Nov 9;14 (11) :728.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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