SKP2 Recombinant Rabbit Monoclonal Antibody [PSH06-22]
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface consisting of ten leucine-rich repeats (LRRs). The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which often—but not always—recognize substrates in a phosphorylation-dependent manner. In this SCF complex, Skp2 acts as the substrate recognition factor.
Product Specifications
Product Name Alternative
Abbreviation
SKP2, FBXL1
Swiss Prot
Q13309 Human, Q9Z0Z3 Mouse,
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthetic peptide within human SKP2 aa 375-424.
Isotype
IgG
Clone
PSH06-22
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
MDA-MB-231 cell lysate, 293T cell lysate, MDA-MB-468 cell lysate, HepG2 cell lysate, SK-OV-3 cell lysate, SH-SY5Y cell lysate, COS-1 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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