SKP2 Recombinant Rabbit Monoclonal Antibody [PSH06-22]
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface consisting of ten leucine-rich repeats (LRRs). The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which often—but not always—recognize substrates in a phosphorylation-dependent manner. In this SCF complex, Skp2 acts as the substrate recognition factor.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
SKP2, FBXL1
Swiss Prot
Q13309 Human, Q9Z0Z3 Mouse,
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthetic peptide within human SKP2 aa 375-424.
Isotype
IgG
Clone
PSH06-22
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
MDA-MB-231 cell lysate, 293T cell lysate, MDA-MB-468 cell lysate, HepG2 cell lysate, SK-OV-3 cell lysate, SH-SY5Y cell lysate, COS-1 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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