Sotorasib-d7
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC)[2][3].
Product Specifications
Product Name Alternative
AMG-510-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Ras
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C=C)N1C([2H])([2H])[C@H](C([2H])([2H])[2H])N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)C([2H])([2H])C1
Molecular Formula
C30H23D7F2N6O3
Molecular Weight
567.64
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Frequently Asked Questions
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