Corosolic acid

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3].

Product Specifications

CAS Number

[4547-24-4]

Product Name Alternative

Colosolic acid

UNSPSC

12352211

Target

Apoptosis; Autophagy; EGFR

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Corosolic-acid.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1

Molecular Formula

C30H48O4

Molecular Weight

472.70

References & Citations

[1]Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64 (5) :468-70.|[2]LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine,  2015-08|[3]Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015 , 29 (5) : 14–723|[4]Ma B, et al. Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. J Exp Clin Cancer Res. 2018 Sep 3;37 (1) :210.|[5]Zhang BY, et al. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178 (6) :1475-1491. |[6]Yang J, et al. Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. Phytomedicine. 2016 Feb 15;23 (2) :181-90.