BP-1-102

BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.

Product Specifications

CAS Number

[1334493-07-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H412

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BP-1-102.html

Concentration

10mM

Purity

99.52

Solubility

DMSO : ≥ 33 mg/mL

Smiles

O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1O

Molecular Formula

C29H27F5N2O6S

Molecular Weight

626.59

Precautions

H302, H315, H319, H335, H412

References & Citations

[1]Zhang X, et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9623-8.|[2]De Simone V, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015 Jul;34 (27) :3493-503.