BP-1-102
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
Product Specifications
CAS Number
1334493-07-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H412
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BP-1-102.html
Concentration
10mM
Purity
99.52
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1O
Molecular Formula
C29H27F5N2O6S
Molecular Weight
626.59
Precautions
H302, H315, H319, H335, H412
References & Citations
[1]Zhang X, et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9623-8.|[2]De Simone V, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015 Jul;34 (27) :3493-503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042883-100 1x 100 µL
Topoisomerase I, Mitochondrial (TOP1MT) (TOP1MT/2883R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC942136-500 1x 500 µL
OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042391-100 1x 100 µL
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details