Dafadine-A
Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1) . Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s[1].
Product Specifications
CAS Number
1065506-69-5
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Dafadine-A.html
Purity
98.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C2=CC=NC=C2)CC1)C3=NOC(COC4=C(C)C=CC=C4C)=C3
Molecular Formula
C23H25N3O3
Molecular Weight
391.46
References & Citations
[1]Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7 (12) :891-3.|[2]Wang X, et al. Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol. Cell Mol Life Sci. 2024 May 22;81 (1) :226.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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