Vitexin-2"-O-rhamnoside

Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases[1][2][3][4][5][6].

Product Specifications

CAS Number

[64820-99-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Caspase; DNA/RNA Synthesis; Interleukin Related; PI3K; SOD

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vitexin-2-o-rhamnoside.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1[C@H](O[C@H](CO)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O

Molecular Formula

C27H30O14

Molecular Weight

578.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei W, et al. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. J Pharm Pharmacol. 2014 Jul;66 (7) :988-97.|[2]Ying X, et al. LC determination of malondialdehyde concentrations in the human umbilical vein endothelial cell culture medium: application to the antioxidant effect of Vitexin-2 ″-O-rhamnoside. Chromatographia, 2008, 67: 679-686. |[3]Cai S, et al. Comparative study on the excretion of vitexin-4''-O-glucoside in mice after oral and intravenous administration by using HPLC. Biomed Chromatogr. 2013 Nov;27 (11) :1375-9.|[4]Wang Y, et al. Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K/Akt signal pathway in cyclophosphamide treated mice. Eur J Pharmacol. 2022 Jun 15;925:174999.|[5]Lu D, et al. Bioavailability of vitexin-2”-O-rhamnoside after oral co-administration with ketoconazole, verapamil and bile salts. Latin Am J Pharm, 2013, 32: 1218-23.|[6]Ninfali P, et al. Characterization and biological activity of the main flavonoids from Swiss Chard (Beta vulgaris subspecies cycla) . Phytomedicine. 2007 Feb;14 (2-3) :216-21.