M-PEG12-amine

M-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[1977493-48-3]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg12-amine.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Molecular Formula

C25H53NO12

Molecular Weight

559.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30 (1) :253-259.|[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.