M-PEG12-amine
M-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
Product Specifications
CAS Number
1977493-48-3
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg12-amine.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Molecular Formula
C25H53NO12
Molecular Weight
559.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30 (1) :253-259.|[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
Frequently Asked Questions
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