m-PEG12-amine
Product Specifications
UNSPSC Description
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg12-amine.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Molecular Weight
559.69
References & Citations
[1]Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259.|[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-140227/m-PEG12-amine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-140227/m-PEG12-amine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1977493-48-3
Available Sizes
Curated Selection
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