Maceneolignan A

Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae) . Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC50 of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC50 of 63.7 μM[1].

Product Specifications

CAS Number

[1967042-42-7]

UNSPSC

12352005

Target

TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/maceneolignan-a.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C([C@H]([C@H](C3=CC(OC)=C(C(OC)=C3)O)O2)C)=CC(/C=C/C)=C1

Molecular Formula

C21H24O5

Molecular Weight

356.41

References & Citations

[1]Morikawa T, et al. Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. J Nat Med. 2018 Mar;72 (2) :464-473.