Maceneolignan A
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae) . Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC50 of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC50 of 63.7 μM[1].
Product Specifications
CAS Number
[1967042-42-7]
UNSPSC
12352005
Target
TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maceneolignan-a.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C([C@H]([C@H](C3=CC(OC)=C(C(OC)=C3)O)O2)C)=CC(/C=C/C)=C1
Molecular Formula
C21H24O5
Molecular Weight
356.41
References & Citations
[1]Morikawa T, et al. Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. J Nat Med. 2018 Mar;72 (2) :464-473.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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