SAMe-1,4-Butanedisulfonate

SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders[1][2][3][4].

Product Specifications

CAS Number

[101020-79-5]

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/same-1-4-butanedisulfonate.html

Concentration

10mM

Purity

98.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(CCCCS(=O)(O)=O)(O)=O.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C[S+](CC[C@H](N)C(O)=O)C)O3.O=S(CCCCS(=O)([O-])=O)([O-])=O.[1/2]

Molecular Formula

C15H23N6O5S·C4H10O6S2·1/2C4H8O6S2

Molecular Weight

725.79

Precautions

H315, H319, H335

References & Citations

[1]Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76 (5) :1172S-6S. |[2]Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187 (2) :74-8. Spanish. |[3]Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27 (10) :1431-3. |[4]Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442.