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M3554

M3554 is an anti-GD2 antibody-drug conjugate (ADC) based on the humanized anti-GD2 antibody. M3554 consists of the humanized monoclonal antibody hu14.18 (K322A) linked to a topoisomerase 1 inhibitor Exatecan (HY-13631) via a cleavable β-glucuronide linker. M3554 can be used for the study of neuroblastoma, osteosarcoma or glioma[1].

Product Specifications

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs) ; CD2; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m3554.html

Purity

99.39

Solubility

10 mM in DMSO

Smiles

[M3554]

Molecular Weight

152639 (average)

References & Citations

[1]Amendt C, et al. Abstract ND08: M3554, a novel anti-GD2 antibody drug conjugate[J]. Cancer Research, 2024, 84 (7_Supplement) : ND08-ND08.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

ADC Related

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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