SB-224289 (hydrochloride)

SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

Product Specifications

CAS Number

[180084-26-8]

Product Name Alternative

SB-224289A

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SB-224289_hydrochloride.html

Purity

99.0

Solubility

DMSO : 4.31 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)N4CCC5=C4C=C6C(OCC67CCN(C)CC7)=C5.Cl

Molecular Formula

C32H33ClN4O3

Molecular Weight

557.08

Precautions

H315, H319, H335

References & Citations

[1]Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11 (5) :e0154932.|[2]Hoplight BJ, et al. The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. Physiol Behav. 2005 Apr 13;84 (5) :707-14. Epub 2005 Apr 13.|[3]Gaster LM, et al. The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. Ann N Y Acad Sci. 1998 Dec 15;861:270-1.