PNC-28 (acetate)

PNC-28 acetate is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 acetate can be used for pancreatic cancer research[1][2].

Product Specifications

UNSPSC

12352209

Target

MDM-2/p53

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pnc-28-acetate.html

Purity

98.79

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[ETFSDLWKLLKKWKMRRNQFWVKVQRG(acetate)]

Molecular Formula

C164H255N47O37S.xC2HF3O2

Molecular Weight

3509.13 (free acid)

References & Citations

[1]Kelley A. Sookraj. QS304. Novel p53-Derived Peptide Induces Rapid Human Pancreatic Cancer Cell Death. 2008, 144 (2), 1.|[2]Michl J, et al. PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. Int J Cancer. 2006 Oct 1;119 (7) :1577-85.