MSIRK

MSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1].

Product Specifications

CAS Number

[593267-11-9]

UNSPSC

12352209

Target

ERK

Type

Peptides

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/msirk.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O

Molecular Formula

C93H150N20O25

Molecular Weight

1948.31

References & Citations

[1]Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278 (22) :19634-41.|[2]Zhang XL, et al. Y27632 induces tongue squamous cell carcinoma cell apoptosis through MAPK-ERK/JNK signal. De Gruyter Brill.