Granotapide
Granotapide (JTT-130) is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces absorption of cholesterol and triglycerides through inhibition of MTP. Granotapide can be used for the research of dyslipidemia[1].
Product Specifications
CAS Number
594842-13-4
Product Name Alternative
JTT-130
UNSPSC
12352005
Target
Microsomal Triglyceride Transfer Protein (MTP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/granotapide.html
Solubility
10 mM in DMSO
Smiles
CCOC(C(C(OCC)=O)(COC(CC1=CC(C(N(C)C)=O)=C(C=C1)NC(C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)=O)=O)C4=CC=CC=C4)=O
Molecular Formula
C39H37F3N2O8
Molecular Weight
718.71
References & Citations
[1]Zhao HP, et al. Discontinued drugs in 2012: cardiovascular drugs. Expert Opin Investig Drugs. 2013 Nov;22 (11) :1437-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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