INU-152

INU-152 is a potent and selective B-Raf inhibitor. INU-152 reduces tumor cell proliferation, enhances autophagy, and induces apoptosis by inhibiting B-Raf activity. INU-152 exhibits significant cytotoxicity against cancer cells transformed with v-Ha-ras (Ras-NIH 3T3) . INU-152 can be utilized in cancer research[1].

Product Specifications

CAS Number

[1380228-30-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; Raf

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/inu-152.html

Smiles

FC(C=CC(NS(=O)(C1=COC=C1)=O)=C2F)=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5

Molecular Formula

C20H13F2N7O3S

Molecular Weight

469.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Ahn JH, et al. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem Biophys Res Commun. 2012 Jan 13;417 (2) :857-63.