Biotinylated Human CCR8 Protein, His, Flag Tag&Avitag™ (Detergent)
Biotinylated Human CCR8 Protein, His, Flag Tag&Avitag (CC8-H82D3) is expressed from human 293 cells (HEK293) . It is a membrane protein, contains complete wild type 7-transmembrane domans (TMD) and extracellular doman (ECD) .
Product Specifications
Background
This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs) . CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine) . It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.
Specifications
This protein carries a polyhistidine tag at the C-terminus and a Flag tag at the C-terminus followed by an Avi tag (Avitag™) . The protein has a calculated MW of 60.5 kDa.
Expression Region
Asp 2 - Ser 345
Host
HEK293
Target
CCR8
Conjugation
Biotin-labeled
Tag
C-10xHis & C-Flag & C-Avi
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Biotinylated Human CCR8 Protein, His,Flag Tag&Avitag (Cat. No. CC8-H82D3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.2-31 ng/mL (QC tested).
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5
Additives
Glycerol
Molecular Weight
60.5 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
HEK293
Species
Human
Preservative
Glycerol
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