Human SLC7A11&SLC3A2 Full Length Protein, Flag, His Tag (Detergent)
Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH) . A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.
Product Specifications
Background
Specifications
Accession Number
Q9UPY5 & P08195
Expression Region
Val 2 - Leu 501 & Glu 2 - Ala 630
Host
HEK293
Target
SLC7A11 & SLC3A2
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis & N-10xHis
Source
Human & Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Additives
Glycerol
Molecular Weight
59.4 kDa & 69.9 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
HEK293
Species
Human & Human
Protein ID
Q9UPY5 & P08195
Preservative
Glycerol
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