Human Alanyl-tRNA Synthetase (AARS)

<strong>Human Alanyl-tRNA Synthetase (AARS)</strong>_x000D_ <strong>Catalog number:</strong> B2012370_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 107.6 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Alanyl-tRNA synthetase cytoplasmic, Alanine-tRNA ligase, AlaRS_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zeng QY, Peng GX, Li G, Zhou JB, Zheng WQ, Xue MQ, Wang ED, Zhou XL. The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase Nucleic Acids Res. 2019 Apr 8;47(6):3072-3085._x000D_ 2: Mahler M, Miller FW, Fritzler MJ. Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review Autoimmun Rev. 2014 Apr-May;13(4-5):367-71._x000D_ 3: Zhang H, Wu J, Lyu Z, Ling J. Impact of alanyl-tRNA synthetase editing deficiency in yeast Nucleic Acids Res. 2021 Sep 27;49(17):9953-9964._x000D_ 4: Zhao X, Han J, Zhu L, Xiao Y, Wang C, Hong F, Jiang P, Guan MX. Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids Int J Biol Sci. 2018 Aug 6;14(11):1437-1444._x000D_ 5: Zhan X, Yan W, Wang Y, Li Q, Shi X, Gao Y, Ye Q. Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China BMC Pulm Med. 2021 Feb 12;21(1):57._x000D_ 6: Shiba K, Ripmaster T, Suzuki N, Nichols R, Plotz P, Noda T, Schimmel P. Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition Biochemistry. 1995 Aug 22;34(33):10340-9._x000D_ 7: Vargas-Rodriguez O, Bakhtina M, McGowan D, Abid J, Goto Y, Suga H, Musier-Forsyth K. Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity J Biol Chem. 2020 Nov 27;295(48):16180-16190._x000D_ 8: Kuo ME, Antonellis A, Shakkottai VG. Alanyl-tRNA Synthetase 2 (AARS2)-Related Ataxia Without Leukoencephalopathy Cerebellum. 2020 Feb;19(1):154-160._x000D_ 9: Kelly P, Hadi-Nezhad F, Liu DY, Lawrence TJ, Linington RG, Ibba M, Ardell DH. Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens PLoS Negl Trop Dis. 2020 Feb 27;14(2):e0007983._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31839000">10: Fine AS, Nemeth CL, Kaufman ML, Fatemi A. Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination J Neurodev Disord. 2019 Dec 16;11(1):29. </a>_x000D_ _x000D_ <strong>Products Related to Human Alanyl-tRNA Synthetase (AARS) can be found at</strong> <a href="https://moleculardepot.com/product-category/Enzymes/"> Enzymes</a>